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It is great news about pramipexole finally being approved. Let's hope it becomes readily available all over very soon. All of the reports, so far, have indicated pramipexole is an effective treatment by itself in the early stages of PD, delaying levodopa therapy, and later as an adjunct to Sinemet. Does anyone have information on the use of pramipexole by itself, after Sinemet treatment has already been started? I have been taking Sinemet for less than a year (also Eldepryl), and would like to try discontinuing the Sinemet, and seeing if the pramipexole and Eldepryl will be sufficient. Before discussing this possiblility with my neuro - I'd like to have some facts to back up my request. Is anyone else thinking of trying this? Linda Herman [log in to unmask]