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Hi, I have been off the list for a while, but I missed not knowing what was being talked about. I have a question also. I have been on Sinemet for 5 years and have been experiencing dyskinesias and pretty severe off times where I can barely move. I recently was started on Permax and I am up to 11/2 .25 mg tablets 3 times a day. My question is this for any of you who have been on Permax for a while - does your body build up a tolerence for the drug like Sinemet? Will there come a time when I can reduce the amount of SInemet? Also I would like to know what maximum doses some of you are taking. I would appreciate any feed back. I have had quite a bit of relief since I started the Permax and feel like I can cope again. Marty Rose