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marty,Donna After having pd for eleven years I too have been plagued with dyskinesia - for the past year. Its very uncomfortable and frustrating. I started on Permax about a month ago in addition to the sinemet 25/100 and eldepryl am already taking. I have end of dose dyskinesia every a.m. approx 3-4 hours after my first meds of the day. Have tried different combinations but can't seem to get it right. Marty I don't understand what u mean by 11/2 .25 tablets three times a day. I was taking up to 2 .25 mg permax 3 times a day but now cut back to 1 .25mg permax 3 times a day plus 5-6 25/100 sinemets and 1 eldepryl Any feedback welcome. Rosemary Paul ***************************************************** Rosemary Paul [log in to unmask] Community Services x3919 *****************************************************