Hello Donna. I usually stay in the background as far as the list is concerned, but when you mentioned your 4 hours of dyskinesia I felt that I had to say something. If my wife takes sinemet Cr late in the day (past noon actually) she has the same problem. However, by switching to regular sinemet her dyskinetic period is 15 minutes or less. (Average about 10 min) Think about taking sinemet as an airplane ride. You take off and fly through the clouds. While going through the clouds there is some turbulence, but soon you burst into the sunshine and the going is smooth until evening. Now you have to land. You can dive through the clouds or you can coast down gently. By diving through the clouds you get out of the bad time quickly. However, if you go down at a gentle slope, it takes a long time to get through them. Slow release often lets you down so gently you have to spend a long time in the clouds. The other trick that we have is to relax as soon as the dyskinesia starts. My wife lays crosswise on the bed with her legs over the side and her head on a pillow. If you strain in any way during the dyskinesias they just last that much longer. Robert Naylor cg for Olive 74/20 At 10:43 AM 7/7/97 -0400, you wrote: >-- [ From: Donna Kipp * EMC.Ver #2.5.02 ] -- > >HELP!! I am 50 and have been diagnosed for almost 11 Years and for the last >couple of week I have been plagued with daily sometimes more periods of 3 >hours of dyskinesis. It is totally exhausting!! During these periods I >usually keep walking or can rest in my recliner. This is totally taking over >my life!! I am willing to try any or all suggestions. I am unable to >correlate it to either over or under medication. I think it is diphasic. I > am taking 3- 50\200 CR, 3- 1mG Permax and 1eldepryl. I tried cutting out >the permax. Increasing Sinemet, decreasing Sinemet. I am ready for any and >all snake oil...Donna > >