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Dear Phil, I have been on Permax on two separate occasions in my P.D. life. Both of which started out bad, but got better side effects-wise. Side effects that I had initially are quite numerous. I had difficulty sleeping, nausea, vomiting, grinding of my teeth, and severe headaches. After a while, they all went away, to be replaced by only sleepiness. Hope this helps, in someway. Sincerely, Jacob Drollinger 26, dx'ed in '88