To add to the storehouse of information about this uniquely individualistic disease, I almost NEVER take meds at nite. My first meds of the day are taken about 11 -12 noon, and the next dose (the last) is taken about 5 to 6 p.m. (depending). This is the same schedule and drug dose I was on prior to my 10/24/94 unilateral pallidotomy. Since the surgery, I no longer have "on's 'n off's" but do get kind of an "antsy" feeling - a restlessness" after approximately 6 hours (from the time the first dose of the day was taken) that indicates to me it's time to take a Sinamet. I might add, in the VERY stress-filled 12 months prior to getting laid off my job on July 7, the PD was very active (for me). I've been free from that stress for 2 solid weeks now and FEEL great - PD-wise. Even the daily profound exhaustion had abated by July 10th. The reason I mention this is because I still DO have stress in my life - one can't 'be human and not. However, it's not that awful, all-day, all-night, 7 day-a-week-grinding-work-related-stress that came with Microsoft's taking someone who was gifted at doing the original job she was hired to do and trying to turn that non-technical-oriented individual into a programmer THAT was on top of the normal job-related stress.. I've begun to think that there's something like an "acceptable PD stress level" which one's system (tho not always one's mind) WILL tolerate to a certain degree. However, at some point, if that invisible stress level is exceeded on a regular daily basis we hit "PD PAYBACK TIME!" That's when the Parkinson's Disease reminds us who's REALLY running the show. Barb Mallut [log in to unmask] -----Original Message----- From: Parkinson's Information Exchange On Behalf Of Bent Willow Sent: Sunday, July 20, 1997 11:22 AM To: Multiple recipients of list PARKINSN Subject: Re: Meds Only at Night? > Mary Ann, > [log in to unmask] > I found your husband's medicine schedule most remarkable, so much so that I > think it should be studied by researchers--17 years on the job since dx and > he only takes PD med at night. I'm curious to know how much PD meds he takes > at night and what other steps you and he have taken to control his PD?? > Barbara Blake-Krebs (55, dx 1984) [log in to unmask] > Jamie only takes * Sinemet* at night, but he takes Eldepryl, Amantadine and Artane in the a.m. He also takes Lopressor (which I sincerely believe has decreased his tremor remarkably) for hypertension, Zyloprim for Gout, and Zantac at night for gastric reflux. He's a regular walking pharmacy. When he comes home at 4 p.m. he take 50/250 of Sinemet. Then at 9:30 p.m. he takes another 50/250 followed by half that dose at 11:30 at night - he then can sleep until 6 a.m. Jamie is a physical chemist and does most of his work at the computer. We maintain a very low-profile existence and avoid stress like the plague. We have a small farm and a large garden, which Jamie thoroughly enjoys. We notice he functions much better in the summer when he gets regular 'garden exercise.' ------- Mary Ann (CG of Jamie 57/17)