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Rosemary, I am sure someone else will address the nausea. I have never had it. I have been able to take all the meds from the beginning without difficulty. However, I do know about the toe curling dystonia. It is so bad. In the first place I do have my son massage my legs and feet as needed ( usually 3 times a week, especially the legs) and I take Klonopin (an anti-siezure medication) at night in order to sleep with as little leg/foot cramps as possible. I'm sure you will get other answers too. Let her know that others know what her feet are feeling. I was taking Sinemet CR 50/200 every 4 hours or so as needed. It was too much at a time and my dystonia/dyskinesia was terrible. Now I take Sinemet CR 25/100 every 2 hours or as needed. This means that I take it every 2 hours on work days and allow myself to shake on days off. I have very little dystonia/dyskinesia now. good luck don't forget how to laugh Marling [log in to unmask] or [log in to unmask]