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Bruce Warr wrote: >>> Bruce Warr <[log in to unmask]> 07/16/97 11:59am>>> Phil, What you describe is known (appropriately enough) as "Restless Legs Syndrome" or RLS. I started having RLS about five years before I was DXed with PD. The symptoms disappeared for a while after I started on PD medication (Amantadine, then Sinemet and Eldepryl). After a while the symptoms re-appeared, much worse than before. I am a clinical researcher and so did a bit of self-research on the phenomenon. The only conclusion I could reach is that at times the RLS seemed to be a side-effect of my PD meds and at other times it seemed to be a withdrawal symptom. After a couple of years the RLS disappeared (along with other common side-effects such as nausea) and it has been about four years since the last occurance. As to relieving the symptoms, my neurologist prescribed Nortripolin (a sleeping pill that is also an anti-depressant) and that helped a bit, but what helped the most (and I'm not trying to be risque) was having an orgasm. Bruce<aka Starman>55/9 Sinemet CR and Mirapex>>>> Bruce, Phil, others: Restless Legs Syndrome usually comes on with rest and can be relieved temporarily with walking, massage or movement. The symptoms are described by patients as occurring at night causing them to come awake several times during the night. This leads to fatigue during the day. About 50% of all people over 65 describe RLS and the exact cause is unknown, although some doctors recommend treatment for iron deficiency. For PD patients RLS will usually respond to a half to a whole Sinemet 25/100 tablet at bedtime every three days. However, most patients experience side effects, such as an advance in the timing of the symptoms: from nighttime to early evening (or afternoon). In those cases doctors prescribe an agonist - pergolide or bromocriptine. Nausea and nasal congestion are reported side effects. If RLS symptoms persist, codeine combined with an agonist gives some relief. More information can be obtained from the National Sleep Foundation, 729 Fifteenth Street, NW, 4th floor, Washington, D.C. 20005. As for Bruce's observation regarding org- uh, . . . state of excitability . . . I'm going to leave a copy of his posting on the bed for my wife to read. Stephan 53/6 <[log in to unmask]>