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Hi My parkie takes the same meds you name. He gets restless, antsy, around 4 or 5pm. Aggravates me during 'Jeopary' at 4:30p here. Odd- that's the name I give it--antsy. His sinemet CR 50/200 are at 6am, 10am, 2pm,7or 8pm. With each dose he also gets permex .25 at 10 and bedtime and 1 1/2 at 6am and 2pm. Elderpryl at bkf and noon. We had our first dose of mirapex at 7pm today. The ND did not stop the permex at all-It's mirapex tab (.125mg ) 1 tab 3Xdaily for one week and then 2 tabs X 3daily. I bet the hallucinations come! Mary CG Mel 76/11