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In an effort to jump over the possible racial slur suggested in the post concerning Mohammed Ali refusing to take his Sinemet, I would like to addresss the larger issue in regards to *why* he doesn't take the med. Not that I 've ever spoken to him about his reasoning (you'll all be shocked out there to realize that I don't even know the man), but I can sympathize with him. My husband also refuses to take Sinemet until he's away from his job. He finds the dyskinesia associated with 'going up' and 'coming down' from Sinemet so devastating, that he is unwilling to take that med during working hours. Furthermore, the onset of the drug is too unpredictable for him to chance dyskinesia occurring during an important meeting. So, Jamie takes Sinemet when he comes home and doesn't have to worry about not being able to move for the 10 minutes to 1/2 hour as the drug is beginning to take affect. Considering that he continues to work even though he's had PD for the past 17 years must mean that he's doing something right. ------ Mary Ann