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Hi Audrey, I started using pycnogenol about 6 months ago due to its strong antioxidant characteristics and its ability to cross the blood/brain barrier (so I read). So far it has had a provided a boost in my energy level. I'm taking 50 mg per day in the AM. This is a low dosage. I read that 1 mg per pound of body weight is recommended. I had trouble with diarrhea at higher dosages so settled on the 50 mg dosage. It has had no effect on my pd symptoms other than the fatigue problem which it has definitely helped. Since antioxidants are getting so much attention I'm banking on the possible slowing of pd progression due to its use. So far so good. BTW, I also take 3000 IU of vitamin E and 1000 mg of vitamin C each day. Just call me an "antioxidant junkie!" Regards, Gray (50/3)