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Katie I think our ND said Mel would eventually go to .5mg three times daily. He's managing his first week very well on .125mg three times daily. I understand this is not a therapeutic level-Next week will double with 2 pills 3 times daily. The next week she will be cutting back on permex and eventually senemet some. He'll eventually be on Mirapex .5 three times daily. Mel is tolerating all very well. Mary CG MEl 76/11 [log in to unmask]