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Diane, My personal experience with Sinemet is : the effect of a change become stable only after some weeks. The effect after a few days means nothing. The answer to your request for help is sending a message to listserv with "nomail" in the body. Your name sounds French, and there is a Jean-Pierre Lucas on my list. A cousin ? Regards Bernard JOLY [log in to unmask] -----Message d'origine----- De: Parkinson's Information Exchange À la place de Diane Lucas Date: jeudi 24 juillet 1997 19.06 À: Multiple recipients of list PARKINSN Objet: Re: my mum Can anyone help? We haved worked out that my Mum suffers from Dyskenisia at the end of the day having had too much Sinnemet. It was suggested by some of you and her doctor that she cut down. So she started to take a half for the last two doses instead of one whole one. She has been doing this for a few days and still getting the dyskenesia and sometimes the tablets do not work at all and she has no mobility. I would appreciate any help Thank You Diane