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I've posted before that Mel was on the Mirapex. Tonight his ND called and we will increase the Mirapex for the second week-then after the second week we will cut back some on the permex and maybe sinemet in time. She moves slowly with medication changing only one thing at a time. Camillia, I always read your posts and identify some with the same concerns. Home Health has been a blessing for Mel and myself. One of the male aides comes 4 night a week to put Mel to bed. Soon we'll get live-in help as I am a heart patient. I too feel there is hope for the newly diagnosed and also the younger PDs. --By the way, the insert does not speak of any research between permex and mirapex and tonight our ND said none has been done. I often think of you and Peter and wish you well. Mary CG Mel 76/11 [log in to unmask]