_____________________________________ __________________________________________ From: Natalie Kontakos on Wed, Jul 23, 1997 3:22 PM Subject: Re: Mohammed Ali To: Tebay, Wendy M Hi Wendy, There is a gene-environment interaction with Alzheimer's disease. Recent studies have found that individuals with the Apolipoprotein E e4 gene who have had head trauma have a much higher risk of Alzheimer's diseae than those without the gene who have had head trauma. I think that a certain proportion of boxers may have ApoE e4 but I don't think that this frequency is higher in boxers (ie. I don't think that a gene like ApoEe4 predisposes you to box). Whether or not there is a similar relationship with Parkinson's ??? (ApoEe4 has consistently shown to be unrelated to PD but an interaction between smoking and the MAOB gene has been reported) Natalie Kontakos Feel free to forward this to the list. I have trouble posting things to everyone and can only respond to individuals. Wendy.M.Tebay @ LMCO.COM ("Tebay, Wendy M (MSMAIL)") 07/22/97 07:41 PM To: PARKINSN @ listserv.utoronto.ca (Multiple recipients of list PARKINSN) @ INET cc: (bcc: Natalie Kontakos) Subject: Re: Mohammed Ali From: Tebay, Wendy M on Tue, Jul 22, 1997 5:40 PM Subject: Re: Mohammed Ali To: PD Listserv Postings There was an article in the Denver Post recently, that talked about the possibility that some boxers may in fact have a gene that predisposes them to getting diseases like pd and other neurological damage from head trauma. That would then explain why some boxers end up with pd or similar, and some don't Wendy Tebay