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-->>>>>>> Next Section <<<<<<< Content-Type: Text/Plain; charset=US-ASCII I participated in the Pramipexo;e (Mirapex) clinical and will give you our titration schedule. PLEASE NOTE THE DIFFERENCE IN AMOUNT, since , except for binders, trial medication is 100% active ingredients whereas the commerecial form is mostly inactive fillers. It looks as though 1 mg of Pramipexole equals 100 mg of Mirapex. We started on 0.5 mg three times a day. Each week the dose was increeased by 0.25 mg per dose until the maximum trial dosage was reached (or the subject started experiencing dibilitating side-effecfs), I was in the lowest dosage group (1.5 mg tid) and only one out of the five of us at Johns Hopkins experiemced any side effects at all. He was stopped at 1.25 mg tid. The highest dosage group was 6 mg tid, and of course they experienced much more side-effeects. (See the literature accompanying the medicine.) For equivalent Mirapex dosage just mutiply the above amounts by 100. (And, yes, I needed a magnifying glass and tweezers to handle the trial pills.) Bruce