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1. consider generic sinemet in 10/100 dosage vs the 25/100 you cited.. with your dosage you have plenty enough carbidopa floatibng in your system. 2 .youre not taking another agonist? if not, thhen u might shoot for 25% reduction in total sinemet consumption with an agonist 3 best wishes John K Mier [log in to unmask] (spiderr on okbridge)