Pantothenic Acid can be purchased at health food stores. Linda Forres=
t's Mom
Title
Preclinical and clinical studies with cysteamine and pantethine =
related
to the central nervous system.
Author
V=E9csei L; Widerl=F6v E
Address
Department of Psychiatry and Neurochemistry, University of Lund,
Sweden.
Source
Prog Neuropsychopharmacol Biol Psychiatry, 14(6):835-62 1990
Abstract
1. Cysteamine is formed by degradation of coenzyme A (CoA) and c=
auses
somatostatin (SS), prolactin and noradrenaline depletion in the =
brain
and peripheral tissues. 2. Cysteamine influences several behavio=
ral
processes, like active and passive avoidance behavior, open-fiel=
d
activity, kindled seizures, pain perception and SS-induced barre=
l
rotation. 3. Cysteamine has several established (cystinosis,
radioprotection, acetaminophen poisoning) and theoretical (Hunti=
ngton's
disease, prolactin-secreting adenomas) indications in clinical
practice. 4. Pantethine is a naturally occurring compound which =
is
metabolized to cysteamine. 5. Pantethine depletes SS, prolactin =
and
noradrenaline with lower efficacy compared to that of cysteamine=
. 6.
Pantethine is well tolerated by patients and has been suggested =
to
treatment of atherosclerosis. The other possible clinical indica=
tions
(alcoholism, Parkinson's disease, instead of cysteamine) are dis=
cussed.
Language
Eng
Unique Identifier
91117784
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MESH Headings
Alcoholism (DT); Animal; Central Nervous System (DE/*PH); Centra=
l
Nervous System Diseases (*DT); Cerebrovascular Disorders (*DT);
Cysteamine (*PD/TU); Human; Pantetheine (*AA/PD/TU); Parkinson D=
isease
(DT)
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Publication Type
JOURNAL ARTICLE; REVIEW; REVIEW, ACADEMIC
ISSN
0278-5846
Country of Publication
ENGLAND
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