My mom (80/6) for the last few years has been on Permax and Eldepryl. Everytime she tried Sinimet she experienced nausea and vomiting. Finally we were referred to a PD specialist in New York, Dr. Enrico Fazzini who told us about Motilium to relieve the nausea. At first we were skeptical about Motilium, especiallly since it is not approved by the FDA, and we would have to order it from Montreal. But after posting to this group and hearing from a number of other PD'ers who use Motilium (thank you Sonia from Denmark!), my mom gave it a try. And the results have been great! She no longer has any nausea and the Sinimet has been of great help. Her balance is much better and her stamina has been greatly enhanced. She has mentioned a small problem that she recently has noticed - the excess amount of Saliva/Phlegm that she finds in her mouth. She thinks that this has only started being a problem since the use of Sinimet. Anybody have any ideas? She has an appointment this Thursday with Dr. Fazzini to review her progress. She is looking forward to changing from Permax to Mirapex to even further her comeback. She hopes to one day be able to return to bicycle riding (which she did until age 73), but realistically will settle for being able to get on and off buses by herself to be more self sufficient. I want to thank everyone for all the great help you have been and hopefully will continue to be - both in informative news on medicines, and in daily inspiration of combatting PD. Thanks to Don, the Kens, the Barbs, Sonia once again, and all the rest of you. Keep up the fight. [log in to unmask]