^^^^^^GREETINGS FROM^^^^^^^^^^ Ivan Suzman 47/10 [log in to unmask] Portland, Maine land of lighthouses 67 deg. F sunny and beautiful *********************************************************** Dear Kathy, Ron, Jerry, Marge and listfriends, THANK YOU all very much for your comments on Pramipexole. I am on 3 x .125 mg/day at this point. For me, it seems to be VERY powerfu, l because at times I am now getting periods of dyskinesia. I am trying to learn how to REDUCE the Sinemet CR 25/100 and the generic 25/100 carbidopa/levodopa ("Sinemet') I am on. So far, I am already down 200 mg of L-dopa /day, from 1300 to 1100. So far, no side effects other than dyskinesias. I did not know that too much CARBIDOPA is possibly a concern.. I will see my local neuro about this, as well as to discuss what's happening with the pramipexole. Two further questions: 1. Can anyone possibly explain more about the AMOUNT of carbidopa that's considered optimal?? I've always wondered why Sinemet 25/100 and Sinemet 10/100, and Sinemet CR 25/250, 25/100, and 50/200 are all available. What symptoms should I watch out for if I'm getting too much carbidopa? 2. Is anyone taking pramipexole at bedtime? I wonder how it effects sleep. Combined with CR, might it be helpful to prevent overnight freezing up? More later, THANK YOU ALL SO MUCH. IVAN [log in to unmask]