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Kathrynne Holden, MS, RD Editor-in-Chief, "Spotlight on Food--nutrition news for people 60-plus" Kathrynne, You said "... if he takes Sinemet with his meals, response can be altered considerably." It takes about 1 hour to 1.5 hour for Sinemet to have an effect on me that I can detect, and the maximum effect comes after that, maybe at 1.75 to 2 hours. I take 6 Sinemet 24/100 and 1 Sinemet CR 25/100 per day. I have two bowls of cereal with milk for breakfast, and usually a moderate serving of meat, fish, beans, or rice for dinner. How long a time before or after a protein meal must I take Sinemet without noticeably diminishing its effect? Baldwin Robertson (62/4) [log in to unmask]