Friends--This is a warning based onPeter's experience with Mirapex. While many have posted either favorable results or no change in the early usage, We are unfiortunately in the small group(I hope) with Mary Ulmer's husband who had an attack of paranoia due to Mirapex. Here's the story: Peter was to have started the 2nd week,and doubledthe dose to 2-0.125mg 3X a day instead of 1. Last night at 9:00PM he had the third Mirapex for the day, and at midnight took 2 of the 10/100 Sinemets as usual. We both went back to sleep---I thought. About 2:00AM I woke, for some unknown reason, as the alarm was set for the next dose at 3AM. Peter was not in the bed. Nor was he in the apartment--his walker was by an open door, and he was nowhere in sight! I grabbed a robe and flashlight and went hunting--within minutes found him sitting dazededly on the curb near the building, leaning against aparked car. He was wearing a Pajama top, boxer shorts, one slipper--it was a cool damp night. I ran back in, grabbed a blanket, couldn't raise him,and called 9ll. He had abrasions on knee and hands. At the emergency room,after some 3 rs. X-Rays showed no broken bones, but he did have a bladder infection. He was admitted, and is in the hospital now. At first he couldn't/wouldn't tell me if he recalled anything about how he got out, why, etc. Hours later he bagan to recount a night of terrors, thinking there was some threat that made him need to get out of the condo. Outside, he soon fell on the sidewalk,thus the abrasions. Then he CRAWLED for perhaops an HOUR around the building, keeping a low profile when cars went byso as niot to be seen by whatever it was he was hiding from! He didn't know how he got to the car where I found him, but thought it was "a family car" and that he had driven it--tried to get in, but it was locked. In bed in the hospital, as this all began to return, he wept with fright and confusion, was so disoriented he thought he was dead, and that I was his mother.... really a bad scene. We have stopped the Mirapex, and mourn the great hopes we had for it. I am sure there are many who can use it well, but wanted to add our warning to Mary Ulmer's--not all PWPs can handle it, and the results are pretty scary--he could have wandered into the street in front of a car, or so far away that I didn't find him soon. Just BE ON GUARD, folks--as I look back I realize he was confused, and restless all day. The meds that save us arepowerful and can also harm us, as we lknow too well, and even Mirapex the Long-Awaited is suspect for some. So it goes--from a very sleepy CG--- Camilla Flintermann, CG for Peter, 78/7, Oxford,Ohio [log in to unmask] * * * * * * * * * * * * * * "Ask me about the CARE list for PD caregivers!" * * * * * * * * * * * * * *