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Katheryn and Delda, The medications mentioned are certainly not harmless. Mellaril and trilafon are both neuroleptics which block dopamine transmission. They are extremely valuable in treating psychotic disorders such as schizophrenia. The cause significant problems for PWP and usually should not be used by us. There is no evidence to my knowledge that they cause PD however. They can cause a parkinson's like syndrome which is present only when the individual is taking the drug. They also can cause Tardive Dyskinesia which at times is not reversible. It also stands to reason that drug induced parkinsonism would b more likely to occur in people who are in the process of developing PD since it blocks dopamine. I would speculate that the people you each know who took these drugs in the past were more susceptible to the drug side-effects because their PD was in the process of developing rather than the PD was caused by the medications. Elavil also known as amitriptyline, is a tricyclic antidepressant and should not cause effects related to dopamine blockade. Charlie Katheryn Saupp wrote: > > -- [ From: Kathryn Saupp * EMC.Ver #2.5.02 ] -- > > Speaking of history -- how many among us, especially YOPPERS, have > taken the > "harmless" psychotropic drugs mileral, elevil, or trilothon in the > past? > Medical catchword is "tartive parkinsonism." -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]