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the noting that l-deprenyl (Eldepryl) taken at bedtime is not wise made by janet paterson seems right on target to me. disturbed sleep from the chemical(s) is disruptive of the needed "rest activities" of the brain. It is torture to keep a person awake for long periods. It is necessary for sub-conscious activities to be completed. I will go so far as to say that hallucinating and imaginary demons - nightmares - may be cause to take minimal meds after several hours before sleeping begins. The pharmacokinetics of Mirapex (I hope to find some data from somewhere) may be such that Peter Flintemann had enough residual to make the through-the-night levodopa dosage much more effective in the negative way - the straw added that broke the camel's back - to curtail his marginal ability to do the "dream work" required. My few hallucinations have only been in night hours in dark rooms. hyperactivity in a too tired brain may be anxiety (fear) leading to dumping of many neurotransmitters. Even late in day caffeine can disturb my sleep. Nancy labels me hyper - and wonders when I will sleep enough. she loses too when I don't stay quiet. janet's focus on educating her self on brain and psyche is reminiscent of my own focus on that when my first marriage fiasco was disturbing me - my life. there was a great increase in my comprehending of me during nine days of a sensitivity training encounter in the summer of 1968. There have been several spurts of learning experience and avid reading binges, but the basic goal of learning eclectically is my path. It is wise to learn well about our medications and our PD special circumstances of acceptance of loss of health. Depression is not "clinical depression" until one loses the spunk to deal with the moment and keep caring. Caring = giving = reason(s) for being. That self-esteem is necessary - spunky people live well though physically unwell. Don IYQ and Stephen Hawking know what it is about. -- ron 1936, dz PD 1984 Ridgecrest, California Ronald F. Vetter <[log in to unmask]> http://www.ridgecrest.ca.us/~rfvetter