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Janet and others, Some observations on this subject: 1. When I used to take Eldepryl, I used to take one 10mg dose each morning only. It worked very well for me and seemed to last the full 24 hour period without problem. 2. I have just checcked the patient information leaflet for Eldepryl which I still have. Amongst other things, it says: "The usual dose of Eldepryl is 10mg taken in the morning." and, "Avoid taking Eldepryl at night." 3. A current medical site I have read, comes up with this interesting quote: <<The half-life of deprenyl in the body is only a few hours; but once it enters the brain, its effects are very long-lasting. The half-life of MAO-B inhibition in humans has been measured to be about 40 days, therefore, deprenyl probably need not be taken daily by persons who do not have a neurological disease.>> This would probably account for the fact that it took a number of weeks for the effects of my withdrawal from Eldepryl to become noticeable. I hope this and what others say are of some help. Ernie. Ernie Peters <[log in to unmask]>