To anyone troubled by foot cramps...I found some very helpful info I'm = going to pass along. Gail Vass Pharmacotherapy of Ancillary PD Symptoms http://pharminfo.com/pubs/msb/pd_focus.html PD patients have trouble with muscular function in general, which = contributes to a variety of symptoms other than tremor, rigidity and bradykinesia. PD patients are = particularly bothered by dysphagia (drooling, difficulty swallowing), nausea, delayed gastric emptying, and = constipation. Foot cramps are another debilitating condition. There are a number of remedies for these = problems, some pharmacologic, some not. For drooling and difficulty swallowing, sucking hard candy or = chewing gum may facilitate the swallow reflex. Anticholinergics are not recommended because they make = the saliva sticky. Nausea, delayed gastric emptying and constipation may respond to cisapride = (Propulsid/Janssen), a prokinetic agent that accelerates gastric emptying and colonic transit. Exercise = and a high-fiber diet also help. There are dopamine receptors in the gut, so delayed gastrointestinal transit = may be due the same disease process on a local level. = For foot cramps, muscle relaxants such as cyclobenzaprine = (Flexeril/Merck) and baclofen (Lioresal/Geigy) may ease the pain. Since cramping can be due to either too much or too = little dopamine (a peak-dose dystonia or a wearing-off effect), changing the Sinemet dose or dosage = schedule or using the sustained release formulation may help. Some patients respond to the = monoamine-oxidase B inhibitor selegiline (Eldepryl/Somerset) or to the dopamine agonists bromocriptine or = pergolide. Injections of botulinum toxin (Botox/Allergan) into the cramping muscle can provide months of = relief. (See also Parkinson's Disease: Treating Foot Cramps). = http://pharminfo.com/pubs/msb/pd_foot.html Parkinson's Disease: Treating Foot Cramps Reprinted from Medical Sciences Bulletin published by Pharmaceutical = Information Associates, Ltd. = Drugs mentioned: = levodopa/carbidopa (Sinemet/Dupont-MSD) = selegiline (Eldepryl/Somerset) = pergolide (Permax/Lilly) = bromocriptine (Parlodel/Sandoz) = trihexyphenidyl (Artane/Lederle) = cyclobenzaprine (Flexeril/Merck) = baclofen (Lioresal/Geigy) = clonazepam (Klonopin/Roche) = botulinum toxin (Botox/Allergan). = Aching and cramping of the feet are common complaints, often occurring = after injury (strains and sprains) or excessive exercise, or in association with arthritis or poor = circulation in the legs. In Parkinson's disease (PD), cramping of the feet is also very common, but = the cause is central rather than peripheral. Foot cramping is just one of several focal dystonias -- = abnormal, sustained tightening of muscles -- that appear to be due to neurochemical abnormalities in the = basal ganglia, that part of the brain involved in PD. Patients show a particular type of cramping = characterized by downward clenching of the toes or inward turning of the foot. Cramping can occur throughout the = day or night, and can be especially annoying when it interferes with sleep. Foot cramping is more common = among those individuals whose PD affects just one side of the body. = Dystonias are often mistaken for other causes of cramping or painful = muscles. Some individuals with orthopedic foot problems, such as =D2hammer toes,=D3 are actually suffering= = from Parkinsonian dystonia. Patients with dystonias may be entirely unaware of any Parkinsonism; = indeed, muscle cramping can precede the onset of Parkinsonian symptoms by years. There are no = laboratory tests that distinguish dystonia from other causes of cramping, although a thorough neurologic = examination and specialized tests should pinpoint the cause. Some dystonic features -- such as = blepharospasm (involuntary closing of the eyelids) or torticollis (involuntary turning of the neck) -- are = common in the general population. = In the PD patient receiving levodopa/carbidopa (Sinemet/DuPont = Pharmaceuticals), focal dystonias may be caused by either too much of the drug or too little. Patients may = experience dystonia when peak drug levels are attained 1 to 2 hours after administration, or hours later = when drug effects wear off. Changing the dose or dosage schedule of Sinemet, or using the sustained-release = product (Sinemet CR) may help. The monoamine-oxidase B inhibitor selegiline (Eldepryl/Somerset) may = also help. A bedtime dose of Sinemet CR, pergolide (Permax/Lilly), or bromocriptine (Parlodel/Sandoz) = may prevent foot dystonia during early- morning hours. Some patients respond to anticholinergics = such as trihexyphenidyl (Artane/Lederle), muscle relaxants such as cyclobenzaprine = (Flexeril/Merck) and baclofen (Lioresal/Geigy), and the anticonvulsant clonazepam (Klonopin/Roche). = Another treatment giving excellent relief is botulinum toxin (Botox/Allergan). Injected into the = dystonic or cramping muscle, botulinum toxin reduces the intensity of the spasms; the effects may = last months after injec-tion. The toxin is also used for Parkinsonian tremors, benign essential tremor, = and a number of dystonias not always associated with PD. These include blepharospasm, torticollis, = dysphonia (cramping of the vocal cords), strabismus (wandering eye), stuttering, and large-muscle spasms = associated with conditions such as stroke, head trauma, and multiple sclerosis. = A careful evaluation of the temporal relationship between foot cramping = and the levodopa dosage schedule should help the physician decide how best to treat this = uncomfortable manifestation of PD. Modifying the levodopa regimen or adding other anti-PD agents can alter = signals from the brain that trigger the contractions, or the muscle itself can be "paralyzed" with = botulinum toxin. (LeWitt PA. UPF Newsl. 1993; #3: 3-4).