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hi camilla you said: > 3. His neuro, who had read the package insert but had no other experience > with Mirapex refused my suggestion (based on the listmember's posts) > that Sinemet be reduced right away. He wanted to "see how P. does > till next appointment",which isn't until 8/22! Thus P. was getting a > dose of dopa which may have put him over the top, plus the bladder > infection. Small wonder he had a problem? small wonder indeed! in a news article posted recently about mirapex/pramipexole, the anticipated reduction in levodopa requirement was 27 percent! if peter's levodopa dosage was not reduced, i think that might qualify as a strong likelihood for levodopa overdose! viz: >--------------------------------------------------- >Date: Thu, 17 Jul 1997 12:20:23 -0300 >Subject: NEWS: Pramipexole - news from Phoenix >--------------------------------------------------- >Use Of Pramipexole Improves Symptoms >In Advanced Parkinson's Patients On Levodopa >--------------------------------------------------- >WESTPORT, Jul 17 (Reuters) - Last week, Reuters Health reported >on a study published in JAMA that showed that pramipexole is >safe and effective short-term treatment for patients with >early-stage Parkinson's disease. Researchers in Phoenix, Arizona, >now report that use of pramipexole, administered concurrently with >levodopa, improves the management of patients with advanced >Parkinson's disease and allows for a reduction in levodopa dosage. > >Dr. Abraham Lieberman of the St. Joseph's Hospital and Medical >Center in Phoenix and other investigators in the Pramipexole >Study Group examined the efficacy of pramipexole in combination >with levodopa in the management of advanced Parkinson's. >Their findings appear in the July issue of Neurology. >... snip ... > >Pramipexole was specifically effective in improving resting tremor, >rigidity, and limb bradykinesia, according to Dr. Lieberman >and colleagues. Moreover, "...addition of pramipexole >resulted in a 27% reduction in the dosage of levodopa." > > ... snip ... > >Neurology 1997;49:162-168. >Copyright 1997 Reuters Limited. >--------------------------------------------------- there, but for grace, ... my quote for the day: --- the illiterate of the 21st century will not be those who cannot read and write but those who cannot learn, unlearn, and relearn Alvin Toffler --- with love and yet more evidence of my stubborn-ness from peter's and your syber sis janet [log in to unmask]