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hi kathie you said: >I have not asked Ron's neuro, who happens to also be my neuro, >about the timing of the Eldepryl yet. The Home Health nurse >and I discussed it, her opinion was that it would not adversely >affect his sleep when combined with Olanzepine, which I >guess will knock him out. i don't know if you get messages by regular e-mail or by digest, but i wanted to let you know that i just posted a big message summarizing current info about selegiline/eldepryl/deprenyl all sources that i have come across mentioning eldepryl dosage are very clear about the timing being no later than noon if the home health nurse is not familiar with pd, i'm afraid i would take her opinion with a grain of salt ron's pharmacist could be an invaluable resource right now who could give you and ron's brother a detailed run-down of his current med usage, as purchased, not as prescribed. seems to me this is critical. and like i said in my earlier message the two night meds, the olanzepine and the eldepryl, [like taking 'downers' and 'uppers' at the same time] seem to me like a dangerous combination for anyone let alone someone with a neurological chemical imbalance >Also, as noted, the washout period for Eldepryl is so long, >what purpose is served by staggering the dose? i believe that the point was made that the washout period ***in the body*** is only a few hours, which would probably explain the 'speed' effect however, the half-life ***in the brain*** is much longer and may even have something to do with the long-term benefits attributed to eldepryl >Your point about his meds actually being the problem >has a lot of merit, especially in that they may be >contributing to a serious sleep disorder, which is >definitely aggravating a paranoid tendency. as ron vetter pointed out sleep deprivation has been used as a very effective means of torture. that 'paranoid tendency' may not even be the 'real ron'. as a matter of interest, could you find out how long he has been taking eldepryl this way? e.g. from his pharmacist? >It has been hard to accept, but no matter what the root of >these problems, they will not be corrected until he is in >a controlled and supervised situation. i agree, but ... i cannot presume to advise you in this difficult situation, kathie but if i encountered this kind of situation myself i would stop the eldepryl at night immediately so as not to keep adding to the problem and i would hope someone would do the same for me if i were in ron's situation >I have stressed to his brother that the place that he chooses for >Ron in Dallas must be PD-savvy, or he is doomed. very good advice >Ron has asked me "Is there a chance I will get better?" for whatever it's worth i feel quite strongly that his problem is related to the eldepryl and was glad to see other cyber-siblings agreeing with this so my answer to ron would be "is the pope Polish?" i don't mean to be a pest about this, kathie but i keep thinking "this could be me - i live alone" brain chemistry - whew ron is very lucky to have you as a friend [and you're both unlucky? to have me as a nag!] with love from your syber-sis janet [log in to unmask]