 |
 |
To ALL, I have seen several postings complaining about "side-effects" from people who have just started taking Mirapex. In most cases what is described are classic symptoms of L-dopa overdose. The sole purpose of taking a dopamine agonist such as Mirapex is to reduce the need for L-dopa (Sinemet), therefor the Sinemet should be reduced. I participated in the clinical trial of Mirapex/Pramipexole, and in my own estimation my need for Sinemet was reduced by 25%. The participants were divided into four groups with each group receiving a different dosage. I was in the lowest dosage group (1.5 mg tid) and to my knowlege no one in the group experienced side-effects that were directly attributable to the trial medication. This would strongly suggest that any "side-effects" expeienced at levels lower thaan this are from the Sinemet, not the Mirapex. FYI the highest dosage group (6 mg tid) did experience some valid side-effects. Bruce 55/9 Sinemet CR & Mirapex