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Good morning, My mother has been on Mirapex now for almost 3 weeks. The first week and half was a very unsettled. Her dyskenesia was much more extreme and for the first time she found herself completely immobile in the middle of the night. I point these reactions out for a couple of reasons. It was very distressing to hear all the stellar reports on Mirapex and instant Sinemet reduction and not enjoy the same experience. My mother was very worried that this new drug that we all had waited for , for so long, was not going to meet close to hopes and expectations. The other issue was that her increased symptoms seem to result from ramping up too fast on the Mirapex. I think this goes back to the " different strokes for different folks" scenario. We quickly dropped her dose of the Mirapex by a third and changed her schedule of introducing the Mirapex to three times the time alloted. Everything is much smoother, better than ever and spirits are high. I believe her high sensitivity to dopamine, the increased dopamine floating in the brain, etc. was causing the gyrations. I caution those having started on Mirapex, and are experiencing problems, that it may be an option to slow down the titration of the Mirapex rather than decreasing the Sinemet. So far we are having luck with this approach. On another subject. Does anyone have any information on "ideopathic" Parkisons or Parkinsonism. My step father was told last week (after being told for the last 10 years he has PD) that he may have Ideopathic PD and Sinemet won't help. We have always told the various neuro's that his Sinemet makes no impact but to no avail. Thanks for listening and best regards to all Bill Brruce G. Warr wrote: > > To ALL, > > I have seen several postings complaining about "side-effects" from > people who have just started taking Mirapex. In most cases what is > described are classic symptoms of L-dopa overdose. The sole purpose > of taking a dopamine agonist such as Mirapex is to reduce the need > for L-dopa (Sinemet), therefor the Sinemet should be reduced. > > I participated in the clinical trial of Mirapex/Pramipexole, and in > my own estimation my need for Sinemet was reduced by 25%. The > participants were divided into four groups with each group receiving > a different dosage. I was in the lowest dosage group (1.5 mg tid) > and to my knowlege no one in the group experienced side-effects that > were directly attributable to the trial medication. This would > strongly suggest that any "side-effects" expeienced at levels lower > thaan this are from the Sinemet, not the Mirapex. > > FYI the highest dosage group (6 mg tid) did experience some valid > side-effects. > > Bruce > 55/9 > Sinemet CR & Mirapex -- Bill Bell ([log in to unmask])