Dear Kathy, We would be very interested in the results of the sinemet reduction. Recently, the neuro started my husband on the Mirapex with no reduction to Sinemet of which he is now taking 25/250 4x a day. The 3 weeks on the progressive Miralpex was an absolute nightmare so he is now off of it and all the neuro said was to see a movement disorder specialistt inb which we have to wait until Oct. to do that. His case was diagnosed 4 years ago and has no tremors however the other symptoms have put him in a wheelchair totally disabled. The progression has been terribly rapid and we were so hoping that the surgery performed in France with the double implants etc. was a glimmer of hope. After speaking with Medtronics we were informed that the FDA is at least 2 years away from approval. We were advised to call our Congressman. Is there anyone else on line who is in this predicament? Would love to hear. [log in to unmask]