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hi kathie something about your friend's med schedule jumped out at me - the timing of the eldepryl in layparkie-terms, my understanding has always been that eldepryl behaves like speed, and is recommended for morning and noon intake only [which is what i do]; definitely NOT at night, due to the potential for sleep disturbance. could it be possible that ron has the instructions reversed? could you run through his total med intake schedule with his pharmacist? his pharmacist could be an invaluable resource as a backup and confirmation of his medical advice. if, in fact, he has been taking eldepryl at night in error for a long time, i wonder if he's suffering from something as simple as chronic sleep deprivation, or at least sleep disturbance? if so, it may be a problem which might manifest itself very slowly. with all the 'brain news articles' i've been posting over the past two years, it has become obvious to me that any long term sleep disturbance can be a very serious and even dangerous health problem, both mentally and physically. it seems to me that his night-time meds are the automobile equivalent of flooring the accelerator and slamming on the brakes at the same time. not a comforting idea for anyone, let alone one with a brain chemistry imbalance. i do hope this helps. please keep us up to date on his situation. he is very lucky to have you acting as his advocate. there but for grace, ... your syber-sis janet [log in to unmask]