dear Listmembers Tolcapone (Tasmar) is a COMT Inhibitor still in clinical trials . It has a new and different function --it prolongs the effective life of levodopa in the brain I have some questions about Tolcapone ---Maybe a listmember could help? In the current trials-- * is tolcapone given to patients taking Sinemet regular and CR? * are any participants taking other parkinson medications such as bromocriptine or pergolide or selegiline or amantadine? * If tolcapone is not now being tested in these combinations when will such tests take place? * is tolcapone ever combined with these other drugs? Thanks Anne Rutherford