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ERVIN_MCCARTHY wrote: > > Does anyone have any knowledge of amentadine including side affects? > > [log in to unmask] Dear Ervin & Joan and interested others: You have read several widely differing accounts of Amantadine. Like other PD drugs it effects everybody differently. On average the drug is good early in the progress of the disease, and useally effectiveness wanes after a few months to a couple of years. (however as stated can last longer in certain people). Probably the most common side effects are anti-cholinergic (especially constipation), but other dopaminergic side effects can also occur. It is interesting, as stated in another post, that this drug was origimally used as an anti-viral drug and the dopaminergic effects were discovered by accident...Much of our dopamine research has resulted as the result of an accidental discovery. Jerry Starr, RPh.