Best Wishes Linda Forrest's Mom Title [Neurodegeneration: aging and dementia. Etiopathogenic role of e= lectron transport disorders. Therapeutic possibilities] Author Kliv=E9nyi P; V=E9csei L Address Szent-Gy=F6rgyi Albert Orvostudom=E1nyi Egyetem, Szeged. Source Orv Hetil, 138(6):331-5 1997 Feb 9 Abstract The neurodegenerative disorders (Parkinson's disease, Alzheimer'= s dementia, Huntington's disease, cerebellar degeneration) are com= mon medical and social problems. The late onset diseases and slow neurodegeneration is connected with excitotoxins and alteration = of mitochondrial electron transport chain. In elderly, congenital a= nd acquired defects of mitochondrial complexes cause formation of f= ree radicals. The overstimulation of excitatory amino acid receptors interfere with the cellular energy metabolism and also forming r= eactive oxygen species. The impaired energy metabolism make neuronal cel= ls vulnerable to the excitotoxic damage. In these ways, excitotoxic= ity may be the final common pathway of neuronal death in a variety of neurodegenerative diseases. Potential therapeutic strategies wou= ld be use receptor antagonist or drugs to bypass energetic defects. Language Hun Unique Identifier 97212146 ---------------------------------------------------------------------= ------- MESH Headings Aged; Aging (*); Alzheimer's Disease (DT/*PP); Calcium Channel B= lockers (TU); Cerebellar Diseases (DT/*PP); Dementia, Senile (DT/*PP); E= lectron Transport; English Abstract; Female; Human; Huntington's Disease (DT/*PP); Male; Middle Age; Monoamine Oxidase Inhibitors (TU); Neuroprotective Agents (TU); Parkinson Disease (DT/*PP); Thiazol= es (TU); Triazines (TU) ---------------------------------------------------------------------= ------- Publication Type JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE ISSN 0030-6002 Country of Publication HUNGARY ---------------------------------------------------------------------= ------- http://www.medscape.com Medscape is produced by Medscape, Inc. All material on this server Copyright =A9 1994, 1995, 1996, 1997 = by the publishers involved. [Click this icon to load the navigation map (0.9Kb)]