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Marling - Our hearts go out to you - those hours must have seemed like the longest hours in your life. I thought I'd share Dick's experience with you in the hope that it helps. When Dick was first started on CR several years ago, he also had severe dystonia with a bit of dyskinesia. He was so uncomfortable and miserable on it that he eventually switched back to regular Sinemet 10/100. Dick is also highly sensitive to Sinemet, and we believe that the CR was in effect giving him an "overdose." He "evened out" the Sinemet flow in his body by taking half a regular 10/100 every two or three hours, and that worked well for awhile. Eventually his need for dopamine increased (a couple of years later, I'd say), so he tried the CR again, and this time was able to tolerate it. It does sound as if you were simply "overdosed" by the amount of medication you were taking. >I was suffering severe dystonia. I went to the neuro today. He said I have >"DID", dystonia & dyskinesia from the Sinemet CR. I seem to be sensitive to >it. > At first I was on 50/200 3 times a day, then he cut it in half, 25/100 3 >times >a day and now only 2 times a day, but I still am having trouble as it begins >to >take effect and when it wears off. In regard to the Permax - I wonder if your doctor would consider Mirapex instead of Permax. Dick wasn't helped by the Permax at all, but the Mirapex has truly been a miracle drug for him. I know it hasn't worked that way for everyone, but we theorize that his extreme sensitivity to Sinemet somehow made this drug the answer for him. He has cut his usual Sinemet intake down to two-thirds of his original dose (back up from 1/2 dose when he started on the Mirapex). >Now he wants me to take Permax(Pergolide). We will be cutting the Sinemet to >once a day and adding the Permax. Good luck, and let us know how it goes. Warmly, Margie Swindler [log in to unmask]