Best Wishes Linda Forrest's Mom
Title
[Neurodegeneration: aging and dementia. Etiopathogenic role of e=
lectron
transport disorders. Therapeutic possibilities]
Author
Kliv=E9nyi P; V=E9csei L
Address
Szent-Gy=F6rgyi Albert Orvostudom=E1nyi Egyetem, Szeged.
Source
Orv Hetil, 138(6):331-5 1997 Feb 9
Abstract
The neurodegenerative disorders (Parkinson's disease, Alzheimer'=
s
dementia, Huntington's disease, cerebellar degeneration) are com=
mon
medical and social problems. The late onset diseases and slow
neurodegeneration is connected with excitotoxins and alteration =
of
mitochondrial electron transport chain. In elderly, congenital a=
nd
acquired defects of mitochondrial complexes cause formation of f=
ree
radicals. The overstimulation of excitatory amino acid receptors
interfere with the cellular energy metabolism and also forming r=
eactive
oxygen species. The impaired energy metabolism make neuronal cel=
ls
vulnerable to the excitotoxic damage. In these ways, excitotoxic=
ity may
be the final common pathway of neuronal death in a variety of
neurodegenerative diseases. Potential therapeutic strategies wou=
ld be
use receptor antagonist or drugs to bypass energetic defects.
Language
Hun
Unique Identifier
97212146
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MESH Headings
Aged; Aging (*); Alzheimer's Disease (DT/*PP); Calcium Channel B=
lockers
(TU); Cerebellar Diseases (DT/*PP); Dementia, Senile (DT/*PP); E=
lectron
Transport; English Abstract; Female; Human; Huntington's Disease
(DT/*PP); Male; Middle Age; Monoamine Oxidase Inhibitors (TU);
Neuroprotective Agents (TU); Parkinson Disease (DT/*PP); Thiazol=
es
(TU); Triazines (TU)
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Publication Type
JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
ISSN
0030-6002
Country of Publication
HUNGARY
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