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Hi Pepperdol, When i started Pergolide I suddenly was short of breath climbing stairs. I also took domperidone. Since stopping the domperidone, the breathlessness has continued (6 months) but seems a little better now. I feel I also catch my breath and sometimes feel short of breath whilst sitting. I can still walk distances without problem, and the symptom feels like "forgetting to breath" because I can overcome some of the problem by making myself breath more when I climb the stairs. It was so coincidental with starting the Pergolide, I feel it is the drug. Hope this is some help. David (49/2) Pepperdol Donaldson wrote: > > My friend, 70 years old, was diagnosed last year with very early PD. His > major complaint was weakness in his legs, when climbing stairs or on an > incline, or when rising from a chair. Three separate neurologists (two of > whom specialize in PD) were uncertain about him having PD until he responded > to Amantadine, which helped but then lost its effect after several weeks. > He also has a history of hypertension and heart disease, with all aspects > under control for the past few years via medication and surgery. He does > take HCTZ, Zocor, Lasix, Coumadin, Aspirin, and Hytrin for his other health > issues, and for PD, he now takes time-released Sinimet (50/200) three times a > day, with Domperidone to control nausea, which had been severe and for which > nothing but Domperidone has worked. > > For the past few months, he has experienced increasing, sudden shortness of > breath not only on the slightest exertion but also when sitting in a chair or > at rest. This is now chronic. His cardiologist says the shortness of breath > is not connected in any way to his heart and pulmonary function tests > indicate that his lungs are not causing the problem. The questions are > these: > > 1. Can PD itself, even at a very mild stage, cause a symptom like shortness > of breath? > > 2. Can Sinimet and/or Domperidone cause such a problem? > > Thanks for any assistance. > > Lucy Pepperdol-Donaldson