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Hi everyone- I have been taking my Pramipexole for several weeks now and I wanted to give everyone an update. I started in the hospital substituting 3.5 mg of Mirapex (pramipexole) for 35 mg of bromocriptine. When I started I was almost totally unable to walk (as my PD progression combined with the residual of my childhood polio to give me a double whammy and knocked me clear into a wheelchair. By the time I started physical therapy I was up to 4 mg and was getting around to a slight degree with a walker. Because of cramping in my back at night I went up to 1.5 mg 3 x per day + 0.5 mg at bedtime. My ambulation improved but I also became severely dyskinetic and my Sinemet was reduced. I had several bad days as I transitioned home. I was unable to walk again and cramping increased. Finally with appropriate cautions Dr. Goetz increased my Mirapex to 6 mg/day (FDA suggested maximum is 4.5 mg/day). That was the push I needed. My walking with the walker improved considerably, and I am doing some walking on my own. It is clear that I am getting a positive response at this time and while I have had some periods of severe dyskinesia I am convinced these can be controlled with some minor sinemet adjustments. Charlie -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]