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Anne Rutherford wrote: > > Hi All, > > Janet's reports on tolcapone were good news > especially if you are only > taking a levodopa/carbidopa medication. > > However many PWP take in a chemical soup of > meds. > I wonder.............Does anyone know what happens if tolcapone > meets a dopamine agonist? > > Would that mixture make waves in the chemical soup? > Perhaps it would dissolve the soup spoon.? > > Anne Rutherford Dear Anne: Nobody knows for sure until tests are run and/or reports of adverse effects are reported. Theorhetically (sp) the tolcapone (COMT Inhibitor) should make more L-Dopa available to the brain and once in the brain should make more Dopamine available at the receptors. With agonists already at the receptors the probable result would be Dopamine toxicity (IE-dyskinesias). The L-Dopa dose would likely have to be reduced, which is the desired result. J. Starr RPh