Marling.... Just a warm huggle at ya 'cause I feel for you, with what you're going thru from this ^@%#* disease and it's meds. Hang in there, sweetie... Love... Barb M ---------- From: Parkinson's Information Exchange on behalf of Marling McReynolds Sent: Thursday, August 14, 1997 7:05 AM To: Multiple recipients of list PARKINSN Subject: Re: permax Hello friends, Last Tuesday I wanted to die. This is serious. I spent 8 hours on my bed, unable to move on my own. Much of my body, legs and arms were moving, but not when I wanted them to. I was sweating terribly, and the contractions/cramps were the worst I have ever experienced in my life. And most of all I had no control of any of it. I laid there and cried. I was suffering severe dystonia. I went to the neuro today. He said I have "DID", dystonia & dyskinesia from the Sinemet CR. I seem to be sensitive to it. At first I was on 50/200 3 times a day, then he cut it in half, 25/100 3 times a day and now only 2 times a day, but I still am having trouble as it begins to take effect and when it wears off. Now he wants me to take Permax(Pergolide). We will be cutting the Sinemet to once a day and adding the Permax. I read the paper with the Permax. Now, I would like to know what it means. What can I expect? My neuro has talked of keeping the dopamine level even in my blood. He said that the Permax has a longer "half-life" than Sinemet? I do not understand this, and I do not know what it means to my body. Thank you for helping me with information and experience. Even though I have been taking Sinemet for nearly 2 years now, I am such a novice. don't forget how to laugh (I will keep trying) Marling McReynolds [log in to unmask] or [log in to unmask]