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Hey Bob, Check your decimal on the total intake of Mirapex - It should read 1.125mg instead of 112.5 mg. - a huge difference. I am happy to hear Nancy's trying it. I am on it now, too and can see a tremendous difference. I have titrated up to 4mg q day - maximum therapeutic dosage- have cut my Sinenet intake by 50%!!!! I am no longer having the hard offs or the tremendous fluctuations you saw at the forum. Right hand and arm dystonia and dyskinesia is significantly improved with the reduction of the Sinemet. An extra gift, I can now type two-handed again, much of the time. Makes for much faster commmunication. I finally dug out my drug card for counterindications to PD drugs. The major drugs to avoid are as follows: Antipsychotic: Haldol, Trilafon, Thorazine, Stelazine, Prolixin, Permitil, Navane, Mellaril, Loxitane Antidepressants: Triavil, Ascendin, Nardil, Parnate Antivomiting: Compazine, Reglan, Torecan Narcotics: Demerol Misc: Serpasil(Reserpine), Raudixin, Rauverid, Wolfina, Harmonyl, Moderil, Rauwiloid Aldomet, Dilantin, Lithium, Buspar That's pretty much it. Good luck with the back surgery. I hope it brings Nancy the relief that BOTH of you need! I will be thinking about you. Keep me p osted. Terrie