 |
 |
Baldwin Robertson wrote: > > My question is: How is the level of dopamine regulated? > Does dopamine inhibit tyrosine hydroxylase or does it inhibit the > expression of the enzyme? What is the specific mechanism for > the inhibition reaction? That is, what are the specific reactions > that accomplish the regulation? Not a biochemist, and I know nothing of the molecular reactions you describe; but I suspect the regulation is done by the neurons that express dopamine for each specific synaptic impulse. I think I read somewhere that excessive dopamine level outside the cell not only is the cause of dyskinesia, but also somehow triggers apoptosis; and that is why the crude therapy of adding dopamine by eating levodopa is viewed with concern by some. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013