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Martha-- I expect you know that we feel Peter's terribly scary reaction to Mirapex was because his neuro DID NOT reduce the Sinemet he was on. I would really question that decision now. Others have written that the agonists should not be combined--get off one before adding another---it may depend howmch Sinemet he's taking, but do be careful! Camilla Flintermann, CG for Peter, 78/7, Oxford,Ohio [log in to unmask] * * * * * * * * * * * * * * "Ask me about the CARE list for PD caregivers!" * * * * * * * * * * * * * *