To those of you who were interested in the study I cited in my last
post:
http://hypnos.m.ehime-u.ac.jp/Congress2/INT.HTM
The things that I thought important and relevant to PD were these in
order of their importance in my opinion (I'm no authority by any means)
and why.
1. HISTAMINE ACTS AS A REGULATOR of some other amino acid transmitters
in the straitum. (Again the researchers do not specifically name out
dopamine but it is an amino acid transmitter!!!)
It is important because histamine did a very astounding thing:
It had the amazing (in my opinion) ability to DECREASE THE CONCENTRATION
of some (might it be ALL?) amino acid transmitters (GABA, glutamate,
etc).in the straitum. If it does the same thing to dopamine then it
can decrease the amount of dopamine by ~50-60%!!!!
(And with my many, varied, & severe allergies I've got SCADS of
histamine floating around in my body). And we already know that certain
drugs may either help or hinder Parkinsonism because they are either
agonists or antagonists to dopamine, but histamine might,( if it is
affected the same as the other transmitters)actually DECREASE THE AMOUNT
of dopamine by 50-60%!!!!
2. The study showed that receptor sites acted differently under ischemic
conditions than they normally did.
This was important to me because when I consulted one of the top
authorities on allergies -Dr. Creticos, John Hopkins)-one objection
he gave to allergies causing my neck muscle spasm was that there were
no histamine receptor sites in that neck muscle. The study seemed
to show that receptor sites act differently under ischemic
conditions.
I have seen other studies that confirm that finding.
3. The researchers think that histamine contributes to neuronal
protection by its regulation of other transmitters (Wouldn't it be
ironic if in protecting neurons it CAUSES Parkinsonism.)
Again, all this is just MY opinion & interpretation and I'm no expert.
(This is not nearly as hard a question as Baldwin's--with QUESTIONS like
THAT who needs ANSWERS?) Anyway, maybe some of you can steer me straight
if I've strayed.
Again, this is just unfiltered talk by a non-expert, and I CERTAINLY
have been wrong before. Thanks, Janet.
