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This week when Barbara started on Mirapex her neurologist gave her a GUIDE provided by Upjohn. For initial treatment it recommends: Week 1 at 0.375 mg (0.125mg three times a day at morning, noon and evening); week 2 at 0.75mg (two 0.125mg three times at day, morning,noon and evening); week 3 at 1.5 mg (two 0.25mg three times a day etc). After week three it has suggested dosing if needed for total daily doses of week 4 2.25mg; week 5 3mg; week 6 3.75mg; week 7 4.5mg. Tablets are available in 0.125mg, 0.25mg, 1.0 mg, and 1.5 mg. The Guide states that Mirapex may be taken without regard to meals, however taking it with food may reduce nausea. We are keeping our fingers crossed. Allan