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In response to Joseph Gibbons question about Miripex. My husband has been on Miripex since he was first DX almost 5 years ago. He was in the test program and had never taken any other medications. We felt he was on the "real" thing and not a placebo because he improved so much. He takes 1.5 mg three times a day. He has been taking (2) 25/100 Sinimet for the past 6 months and he does seem to have more energy. I believe Miripex is proving beneficial for both "rookies" and "old timers". Rosemary CG for Dex 73/4.5