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Hi Steve, As promised two abstracts. Maybe it gets you thinking. Kees Paap My provider wouldn't let me send it in one file, so i cut it in 2. =============================================================== P105 Tremor in association with periphal neuropathy Y. Mimori*, H. Kamei, C. Sakata, M. Mimori, T. Kohriyama, F. Ishizaki & S. Nakamura The Third Dept. Of Internal Medicin, HiroshimaUniversity School of Medicin, Hiroshima Japan. We investigated 12 patients with neuropathy and tremor to clarify the characteristics and the pathophysiologic basis of tremor. Five patients with chronic inflammatory demyelinating polyneuropathy, two with alcoholic neuropathy, one with Guillain-Barre syndrome, one with vasculitic neuropathy, one with drug-induced neuropathy and one with diabetic neuropathy were included. The duration of tremor ranged from two months to 20 years. All 12 patients showed postural tremor of the hands and four also had tremor of the head or in the lower limbs. The tremor was unrelated to muscle weakness or sensory difficit and the peak frequency varied between 5.5 and 9.4 Hz. In five patients their tremor appeared according the exacerbation of the disease activity and dimished with remission in three cases of neuropathy, indicating the overlap with essential tremor. The peak frequency of eight patients gradually decreased with increasing load attached to the hand suggesting the similar mechanism to enhanced physiological tremor. The frequency from one patient however, remained stable irrespective of changes in load and in thispattern was compatibe with essential tremor. The pathogenesis of neuropathy-associated tremor seems heterogenous and different considerations are necessary for its treatment. Movement Disorders vol 9/supp 1/1994