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On Fri, 29 Aug 1997, Jackie Gilman wondered: > My husband, Bob, (46/5yr.) began taking Mirapex on 8/6/97. > > Prior to this he was taking: 2 Eld., 3 Permax (1mg), and 5 25/100 CR. > > After slowly (over a 3 week period) he substituted a Mirapex (1.0) for a = > Permax and cutting back to 3 or 4 25/100 CRs a day, and adding one more = > Mirapex (for a total of 4.0 mg. per day)... Bob is not doing well at = > all. > > He has NO dyskinesia, but he has extreme stiffness and extreme = > bradykinesia. Prior to all of this he functioned pretty well, now he = > only has about 2 hours at three times each day where he is functional. = > He feels greatly pressured and very, very restless - to put it mildly = > (uncontrollably), he paces the floor all night and even though he is = > very tired he can not sleep (he has had a total of 6 hours sleep in the = > last four days!). I spoke to the nurse and they prescribed = > Amitriptyline (10 mg) for sleep. We realize this may take a few days = > before it will work. =20 > > Since Bob did not seem to be having any good or bad effects from the = > Mirapex initially, we did not think all of the above could be from the = > Mirapex, but now we are not so sure. Needless to say, I will be calling = > the Dr. tomorrow. Has anyone else had these effects?=20 > > Thanks for any advice. > > Jackie Jackie Bob may have cut back too much on the Sinemet. I was in the study and did not cut back my Sinemet at all. But the effectiveness of the Mirapex was demonstrated my the fact that during those three years I did not have to increase the Sinemet either! Bruce 55/9 Sinemet CR and Mirapex * What mid-age crises? I'm too busy enjoying my second child-hood! *