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The mentions of serotonin and tryptophan caught my eye, as I had just read an article sent me by DelAna Vaughan (listmember) on "Drugs inducing or aggravatin g Parkinsonism" (Therapie 1996:51:568-577) The major thrust of studies was drug induced PD-like states, butthey also studied idiopathic PD. I quote briefly the following for what it's worth: "There is both experimental and clinical evidence to suggest a role for serotonin in Parkinson's disease. Inpatients with PD, the concentration of total serotonin in CSF had significant negative correlations with Hoehn & Yahr' stages, and the severity of rigidity, akinesia, and gait freezing.......(also) tryptophan and papaverine, interacting with levadopa, may aggravate motor sympt oms in a parkinsonian patient ,but their capacity to induce parkinsonism by the mselves is uncertain." This suggests to me that one who is taking levadopa should be careful of tryptophan. Do others have info aboutthis effect? There are other interesting points in the article re: drug interactions which I'll try to share later on. Camilla Flintermann, CG for Peter, 78/7, Oxford,Ohio [log in to unmask] * * * * * * * * * * * * * * "Ask me about the CARE list for PD caregivers!" * * * * * * * * * * * * * *